Excitement about induced pluripotent stem cells

There’s been a lot of interest in this article: Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts, by Masato Nakagawa and 9 co-authors (including Shinya Yamanaka), Nature Biotechnology, Advanced online publication, 30 November 2007. As of this morning, the full text is still freely accessible.

For the current news about this topic, see, for example, a Google News search for the key words: Yamanaka stem cell

Two earlier papers about induced pluripotent stem cells, both published online on November 20, 2007, also generated interest. They are (see also my comment posted to this blog on November 20):

1) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, by Kazutoshi Takahashi and co-authors (including Shinya Yamanaka), published in Cell. [Cell DOI: 10.1016/j.cell.2007.11.019]. PDFs of the article and supplemental data are currently freely accessible via the Cell website.

2) Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells, by Junying Yu and co-authors (including James A. Thomson), published in Science. [Science DOI: 10.1126/science.1151526]. Only the abstract is currently freely accessible.

Cell has highlighted the free access to the first of these two articles published on November 20. See: Yamanaka paper in Cell captivates the world (undated). Excerpts:

Media from around the world were captivated by the Yamanaka paper published in Cell earlier this week. Over 300 stories about the research appeared online within 2 hours after being posted online, with nearly 800 stories by 3pm that day.

A full list of coverage can be found at: http://news.google.com/nwshp?tab=wn&q=yamanaka+stem+cell&ie=UTF-8

However, as of today, most of the coverage was about the subsequent article that was published online in Nature Biotechnology on November 30.



  1. tillje said

    See also: Induced pluripotent stem cells used for therapy, by Greg Dahlmann, blog.bioethics.net, December 6, 2007. This is a commentary about an article, Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin, by Jacob Hanna and 10 co-authors (including Rudolf Jaenisch), published online in Science on December 6, 2007. Only the abstract is currently freely accessible.

  2. tillje said

    Reprogramming Cells was ranked #2 (after Human Genetic Variation, the “Breakthrough of the Year” ) by Science. Published in Science 2007(21 Dec); 318(5858): 1844. The full text is freely accessible.

  3. tillje said

    A freely accessible “Research Highlights” commmentary, Adult cells reprogrammed to pluripotency, without tumors, by Monya Baker, was published online in Nature Reports Stem Cells on December 6, 2007.

    This commentary is also accessible via: doi:10.1038/stemcells.2007.124.

  4. tillje said

    The Wikipedia entry for Induced pluripotent stem cell includes some comments about the genes used for the induction.

  5. tillje said

    See also: Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes, to Pluripotency, by Jacob Hanna and 12 co-authors, including Rudolf Jaenisch, Cell 2008(18 April); 133(2), 250-264. [PubMed Abstract].

    For a brief commentary, see: Mini-research round-up, “Reprogramming turns an end to a beginning”, posted by Monya Baker, the niche, April 17, 2008.

  6. tillje said

    For some recent news about induced pluripotent stem cells (iPS), see: Stem Cell Update: Welcome New iPS Cell Lines! Blog.bioethics.net, August 7, 2008. Excerpt:

    … stem cells researchers have been quietly announcing truly spectacular work – the creation of 11 induced pluripotent stem (iPS) (aka “reprogrammed” ) cell lines from sick people.

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