A news item, Newly created cancer stem cells could aid breast cancer research, by Alyssa Kneller, Whitehead Institute for Biomedical Research (13 August 2007) is about an article, “Transformation of Different Human Breast Epithelial Cell Types Leads to Distinct Tumor Phenotypes”, Cancer Cell 2007(14 Aug); 12(2): 160-170. The authors are Tan A. Ince, Andrea L. Richardson, George W. Bell, Maki Saitoh, Samuel Godar, Antoine E. Karnoub, James D. Iglehart and Robert A. Weinberg.
The full text isn’t freely accessible from this Cell Press journal. (For previous posts to this blog about Cell Press journals, see: Paying a fee for Green OA, and Stem cell research). Only the Summary is accessible without a subscription:
We investigated the influence of normal cell phenotype on the neoplastic phenotype by comparing tumors derived from two different normal human mammary epithelial cell populations, one of which was isolated using a new culture medium. Transformation of these two cell populations with the same set of genetic elements yielded cells that formed tumor xenografts exhibiting major differences in histopathology, tumorigenicity, and metastatic behavior. While one cell type (HMECs) yielded squamous cell carcinomas, the other cell type (BPECs) yielded tumors closely resembling human breast adenocarcinomas. Transformed BPECs gave rise to lung metastases and were up to 10[power]4-fold more tumorigenic than transformed HMECs, which are nonmetastatic. Hence, the pre-existing differences between BPECs and HMECs strongly influence the phenotypes of their transformed derivatives.
A PubMed search for articles authored by RA Weinberg yielded a set of 301 articles. (The article cited above hadn’t been indexed by PubMed yet). Of these 301 articles, links to free full text were provided via PubMed for 108 (36%). Of the most recent 20 articles, 6 have PubMed links to free full text (30%). Searches via Google Scholar and Google quickly revealed free full text versions of 7 of the 14 other articles in the 20 most recent articles indexed by PubMed, for a total of 13/20 (65%). Usually, these latter free full text versions were available because an embargo period had elapsed.
In subsequent posts, I hope to provide more examples of this kind. My reason for an interest in such examples? It’s the leading researchers in various fields of research and scholarship who serve as role models for their more junior colleagues.